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aromatase expression is increased in brca1 mutation carriers在brca1突变携带者芳香化酶表达增加
BMC Cancer BioMed Central
Research article Open Access
Aromatase expression is increased in BRCA1 mutation carriers
1 2 1,3 1,3
Ashwini L Chand* , kConFab , Evan R Simpson and Colin D Clyne
Address: 1Prince Henrys Institute of Medical Research, P.O. Box 5152, Clayton, Victoria 3168, Australia, 2Kathleen Cuningham Foundation
Consortium for Research into Familial Breast Cancer, Melbourne, Victoria, Australia and 3Dept. of Biochemistry, Monash University, Clayton,
Victoria, Australia
Email: Ashwini L Chand* - ashwini.chand@; kConFab - heather.thorne@;
Evan R Simpson - evan.simpson@; Colin D Clyne - colin.clyne@
* Corresponding author
Published: 16 May 2009 Received: 11 December 2008
Accepted: 16 May 2009
BMC Cancer 2009, 9:148 doi:10.1186/1471-2407-9-148
This article is available from: /1471-2407/9/148
© 2009 Chand et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Until recently, the molecular mechanisms explaining increased incidence of ovarian
and breast cancers in carriers of BRCA1 gene mutations had not been clearly understood. Of
significance is
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