原创力文档association analysis of adprt1, akr1b1, rage, gfpt2 and pai-1 gene polymorphisms with chronic renal insufficiency among asian indians with type-2 diabetes协会的分析adprt1 akr1b1,愤怒,gfpt2 pai-1基因多态性与慢性肾功能不全与2型糖尿病在亚洲的印度人.pdfVIP
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association analysis of adprt1, akr1b1, rage, gfpt2 and pai-1 gene polymorphisms with chronic renal insufficiency among asian indians with type-2 diabetes协会的分析adprt1 akr1b1,愤怒,gfpt2 pai-1基因多态性与慢性肾功能不全与2型糖尿病在亚洲的印度人
Prasad et al. BMC Medical Genetics 2010, 11:52
/1471-2350/11/52
RESEARCH ARTICLE Open Access
Association analysis of ADPRT1, AKR1B1, RAGE,
GFPT2 and PAI-1 gene polymorphisms with
chronic renal insufficiency among Asian Indians
with type-2 diabetes
1 1 2 3 4 5 1*
Pushplata Prasad , Arun K Tiwari , KM Prasanna Kumar , AC Ammini , Arvind Gupta , Rajeev Gupta , BK Thelma
Abstract
Background: To determine association of nine single nucleotide polymorphisms (SNPs) in ADP ribosyltransferase-1
(ADPRT1), aldo-keto reductase family 1 member B1 (AKR1B1), receptor for advanced glycation end-products (RAGE),
glutamine:fructose-6-phosphate amidotransferase-2 (GFPT2), and plasminogen activator inhibitor-1 (PAI-1) genes
with chronic renal insufficiency (CRI) among Asian Indians with type 2 diabetes; and to identify epistatic
interactionss between genes from the present study and those from renin-angiotensin-aldosterone system (RAAS),
and chemokine-cytokine, dopaminergic and oxidative stress pathways (previously investigated using the same
sample set).
Methods: Type 2 diabetes subjects with CRI (serum creatinine ≥3.0 mg/dl) constituted the cases (n = 196), and
ethnicity and age matched individuals with diabetes for a duration of ≥ 10 years, normal renal functions and
normoalbuminuria recruited as controls (n = 225). Allelic and genotypic constitution of 10 polymorphisms (SNPs)
from five genes namely- ADPRT1, AKR1B1, RAGE, GFPT2 and PAI-1 with diabetic CRI was investigated. The genetic
associations were evaluated by computation of odds ratio and 95% confidence interval. Multiple logistic regression
analysis was carried out to correlate various clinical parameters with genotypes, and to study epistatic interactio
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