原创力文档association between 9p21 genetic variants and mortality risk in a prospective cohort of patients with type 2 diabetes (zodiac-15)9 p21基因变异和死亡率之间的关联在2型糖尿病患者的前瞻性群组(zodiac-15).pdfVIP
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association between 9p21 genetic variants and mortality risk in a prospective cohort of patients with type 2 diabetes (zodiac-15)9 p21基因变异和死亡率之间的关联在2型糖尿病患者的前瞻性群组(zodiac-15)
Landman et al. Cardiovascular Diabetology 2012, 11:138 CARDIO
/content/11/1/138 VASCULAR
DIABETOLOGY
ORIGINAL INVESTIGATION Open Access
Association between 9p21 genetic variants and
mortality risk in a prospective cohort of patients
with type 2 diabetes (ZODIAC-15)
1*† 2,3† 1,4,5 1 1
Gijs WD Landman , Jana V van Vliet-Ostaptchouk , Nanne Kleefstra , Kornelis JJ van Hateren , Iefke Drion ,
6 5 7 2 1,5,8
Klaas H Groenier , Rijk OB Gans , Harold Snieder , Marten H Hofker and Henk JG Bilo
Abstract
The genomic region at 9p21 chromosome near the CDKN2A/CDKN2B genes is associated with type 2 diabetes(T2D)
and cardiovascular disease(CVD). The effect of the 9p21 locus on long-term mortality in patients with T2D has yet
to be determined.
We examined three single nucleotide polymorphisms (SNPs) on 9p21, consistently and independently associated
with T2D (r or CVD (r rs2383206), in relation to the risk of total and cardiovascular mortality in
diabetic patients. We also aimed to replicate the previously observed interaction between rs2383206 and glycemic
control on mortality.
Genotypes for three SNPs were determined in 914 individuals from a prospective cohort of T2D patients of Dutch
origin. Associations with mortality were assessed using Cox proportional hazard analyses.
After a median follow
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