arraymining a modular web-application for microarray analysis combining ensemble and consensus methods with cross-study normalizationarraymining模块化的一点微阵列分析合奏和共识方法结合cross-study正常化.pdfVIP

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arraymining a modular web-application for microarray analysis combining ensemble and consensus methods with cross-study normalizationarraymining模块化的一点微阵列分析合奏和共识方法结合cross-study正常化.pdf

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arraymining a modular web-application for microarray analysis combining ensemble and consensus methods with cross-study normalizationarraymining模块化的一点微阵列分析合奏和共识方法结合cross-study正常化

BMC Bioinformatics BioMed Central Software Open Access ArrayMining: a modular web-application for microarray analysis combining ensemble and consensus methods with cross-study normalization Enrico Glaab, Jonathan M Garibaldi and Natalio Krasnogor* Address: School of Computer Science, Nottingham University, Jubilee Campus, Wollaton Road, Nottingham, UK Email: Enrico Glaab - enrico.glaab@cs.nott.ac.uk; Jonathan M Garibaldi - jmg@cs.nott.ac.uk; Natalio Krasnogor* - nxk@cs.nott.ac.uk * Corresponding author Published: 28 October 2009 Received: 8 May 2009 Accepted: 28 October 2009 BMC Bioinformatics 2009, 10:358 doi:10.1186/1471-2105-10-358 This article is available from: /1471-2105/10/358 © 2009 Glaab et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Statistical analysis of DNA microarray data provides a valuable diagnostic tool for the investigation of genetic components of diseases. To take advantage of the multitude of available data sets and analysis methods, it is desirable to combine both different algorithms and data from different studies. Applying ensemble learning, consensus clustering and cross-study normalization methods for this purpose in an almost fully automated process and linking different analysis