原创力文档argonaute proteins potential biomarkers for human colon cancerargonaute蛋白质人类结肠癌的潜在生物标志物.pdfVIP
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argonaute proteins potential biomarkers for human colon cancerargonaute蛋白质人类结肠癌的潜在生物标志物
Li et al. BMC Cancer 2010, 10:38
/1471-2407/10/38
RESEARCH ARTICLE Open Access
Argonaute proteins: potential biomarkers for
human colon cancer
1 1 2* 1*
Lan Li , Chaohui Yu , Hengjun Gao , Youming Li
Abstract
Background: Although Argonaute proteins are considered to play important roles in stem cell self-renewal, RNA
interference (RNAi) and translational regulation, relatively little is known about their functions in human disease. In
this study, we investigated the expression of eight members of human Argonaute family in colon cancer and
identified their potential roles in tumor development and progression.
Methods: Antibodies against human Argonaute proteins were prepared by immunizing rabbits with synthetic
peptides derived from the sequences of Argonaute members. Then we constructed a tissue microarray containing
75 specimens from colon cancer and 75 specimens from adjacent non-cancer tissue, and assayed eight different
proteins (EIF2C1, EIF2C2, EIF2C3, EIF2C4, PIWIL1, PIWIL2, PIWIL3 and PIWIL4) by immunohistochemistry on
consecutive formalin-fixed tissue microarray sections.
Results: The expression of EIF2C1-4 and PIWIL1-4 was significantly higher in tumorous tissue than in adjacent
tissue. Notably, a significant correlation was observed between the positive expression of EIF2C2, EIF2C3, EIF2C4,
PIWIL4 and the presence of distant metastasis. Logistic regression analysis revealed that an increased expression of
EIF2C1 and PIWIL2 was significantly associated with occurrence of colon cancer tissue compared with non-cancer
tissue.
Conclusions: Argonaute proteins are overexpressed in colon cancer relative to adjacent non-cancer tissue. The
expression of EIF2C2-4 and PIWIL4 appears increased in advanced tumors with distant metastasis, suggestin
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