arterial wall properties and womersley flow in fabry disease动脉壁的属性和womersley流动fabry疾病.pdfVIP

BMC Cardiovascular Disorders BioMed Central BMC Cardiovascular Disorders 2 2002, Research article Arterial Wall Properties and Womersley Flow in Fabry Disease David F Moore 1, Gheona Altarescu 1, Randall Pursley 2, Umberto Campia 4, Julio A Panza 4, Emilios Dimitriadis 3 and Raphael Schiffmann * 1 Address: 1Developmental and Metabolic Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA, 2Center for Information Technology, National Institutes of Health, Bethesda, MD, USA, 3Division of Bioengineering and Physical Science, Office for Research Services, National Institutes of Health, Bethesda, MD, USA and 4Cardiovascular Research Institute, Washington Hospital Center, D.C., USA E-mail: David F Moore - dfm1@; Gheona Altarescu - altaresg@; Randall Pursley - pursley@; Umberto Campia - umberto.campia@; Julio A Panza - panzaj@; Emilios Dimitriadis - dimitria@; Raphael Schiffmann* - rs4e@ *Corresponding author Published: 10 January 2002 Received: 16 November 2001 Accepted: 10 January 2002 BMC Cardiovascular Disorders 2002, 2:1 This article is available from: /1471-2261/2/1 © 2002 Moore et al; licensee BioMed Central Ltd. Verbatim copying and redistribution of this article are permitted in any medium for any purpose, provided this notice is preserved along with the articles original URL. Abstract Background: Fabry disease is an X-linked recessive lysosomal storage disease resulting in the cellular accumulation of globotriaosylceramide particularly globotriaosylceramide. The disease is characterized by a dilated vasculopathy with arterial ectas