anti-proliferative effect of extremely low frequency electromagnetic field on preneoplastic lesions formation in the rat liveranti-proliferative极低频电磁场对肿瘤出现前的河鼠肝脏病变形成.pdfVIP

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anti-proliferative effect of extremely low frequency electromagnetic field on preneoplastic lesions formation in the rat liveranti-proliferative极低频电磁场对肿瘤出现前的河鼠肝脏病变形成.pdf

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anti-proliferative effect of extremely low frequency electromagnetic field on preneoplastic lesions formation in the rat liveranti-proliferative极低频电磁场对肿瘤出现前的河鼠肝脏病变形成

Jiménez-García et al. BMC Cancer 2010, 10:159 /1471-2407/10/159 R E S E A R C H A R T I C L E Open Access Research article Anti-proliferative effect of extremely low frequency electromagnetic field on preneoplastic lesions formation in the rat liver 1 2 2 Mónica Noemí Jiménez-García , Jaime Arellanes-Robledo , Diana Ivette Aparicio-Bautista , Miguel Ángel Rodríguez- 1 2 1 Segura , Saúl Villa-Treviño and Juan José Godina-Nava* Abstract Background: Recently, extremely low frequency electromagnetic fields (ELF-EMF) have been studied with great interest due to their possible effects on human health. In this study, we evaluated the effect of 4.5 mT - 120 Hz ELF-EMF on the development of preneoplastic lesions in experimental hepatocarcinogenesis. Methods: Male Fischer-344 rats were subjected to the modified resistant hepatocyte model and were exposed to 4.5 mT - 120 Hz ELF-EMF. The effects of the ELF-EMF on hepatocarcinogenesis, apoptosis, proliferation and cell cycle progression were evaluated by histochemical, TUNEL assay, caspase 3 levels, immunohistochemical and western blot analyses. Results: The application of the ELF-EMF resulted in a decrease of more than 50% of the number and the area of γ- glutamyl transpeptidase-positive preneoplastic lesions (P = 0.01 and P = 0.03, respectively) and glutathione S- transferase placental expression (P = 0.01). The number of TUNEL-positive cells and the cleaved caspase 3 levels were unaffected; however, the proliferating cell nuclear antigen, Ki-67, and cyclin D1 expression decreased significantly (P ≤ 0.03), as compared to the sham-exposure group. Conclusion: The application of 4.5 mT - 120 Hz ELF-EMF inhibits pr