antispasmodic and vasodilator activities of morinda citrifolia root extract are mediated through blockade of voltage dependent calcium channels抗痉挛药和血管舒张活动morinda citrifolia根的提取物通过电压依赖性钙通道的封锁.pdfVIP

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antispasmodic and vasodilator activities of morinda citrifolia root extract are mediated through blockade of voltage dependent calcium channels抗痉挛药和血管舒张活动morinda citrifolia根的提取物通过电压依赖性钙通道的封锁.pdf

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antispasmodic and vasodilator activities of morinda citrifolia root extract are mediated through blockade of voltage dependent calcium channels抗痉挛药和血管舒张活动morinda citrifolia根的提取物通过电压依赖性钙通道的封锁

Gilani et al. BMC Complementary and Alternative Medicine 2010, 10:2 /1472-6882/10/2 RESEARCH ARTICLE Open Access Antispasmodic and vasodilator activities of Morinda citrifolia root extract are mediated through blockade of voltage dependent calcium channels Anwarul Hassan Gilani1,3*, Saf-ur-Rehman Mandukhail1,2†, Javeid Iqbal2†, Masoom Yasinzai2†, Nauman Aziz1†, Aslam Khan1†, Najeeb-ur-Rehman1† Abstract Background: Morinda citrifolia (Noni) is an edible plant with wide range of medicinal uses. It occurs exclusively in tropical climate zone from India through Southeast Asia and Australia to Eastern Polynesia and Hawaii. The objective of this study was to explore the possible mode(s) of action for its antispasmodic, vasodilator and cardio- suppressant effects to rationalize its medicinal use in gut and cardiovascular disorders. Methods: Isolated tissue preparations such as, rabbit jejunum, rat and rabbit aorta and guinea pig atria were used to test the antispasmodic and cardiovascular relaxant effects and the possible mode of action(s) of the 70% aqueous-ethanolic extract of Morinda citrifolia roots (Mc.Cr). Results: The Mc.Cr produced a concentration-dependent relaxation of spontaneous and high K+ induced contractions in isolated rabbit jejunum preparations. It also caused right ward shift in the concentration response curves of Ca++, similar to that of verapamil. In guinea-pig right atria, Mc.Cr caused inhibition of both atrial force and rate of spontaneous contractions. In rabbit thoracic aortic preparations, Mc.Cr also suppressed contractions induced by phenylephrine (1.0 μM) in normal- Ca++ ++ + and Ca -free Kerb’s solutions and by high K , similar to that of verapamil. In r