原创力文档anti-spasmodic action of crude methanolic extract and a new compound isolated from the aerial parts of myrsine africana原油anti-spasmodic行动methanolic提取和一种新的化合物分离从空中myrsine非洲部分地区.pdfVIP
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anti-spasmodic action of crude methanolic extract and a new compound isolated from the aerial parts of myrsine africana原油anti-spasmodic行动methanolic提取和一种新的化合物分离从空中myrsine非洲部分地区
Azam et al. BMC Complementary and Alternative Medicine 2011, 11:55
/1472-6882/11/55
RESEARCH ARTICLE Open Access
Anti-spasmodic action of crude methanolic
extract and a new compound isolated from the
aerial parts of Myrsine africana
1 2 1*
Sadiq Azam , Shumaila Bashir and Bashir Ahmad
Abstract
Background: Myrsine africana is an herbaceous plant that is traditionally used as appetizer and carminative. Locally,
it is used for the treatment of pulmonary tuberculosis, rheumatism and diarrhea by healers. The aims of the current
study were to screen the crude methanol extract obtained from the aerial parts (leaves and stem) of M. africana,
for antispasmodic actions on isolated tissues and further to subject the ethyl acetate (EtOAc) fraction of plant to
column chromatography for isolation of pure compounds.
Methods: The antispasmodic action of the crude methanol extract was measured on the spontaneous rabbit’s
jejunum preparations at concentration 0.01, 0.03, 0.1, 0.3, 1.0, 5.0 and 10.0 mg/ml. The crude extract was also
applied, in similar concentrations, on KCl (80 mM) induced contractions to explain its possible mode of action.
Results: A new compound Myrsigenin was isolated from the EtOAc fraction of M. africana. The structure of the
compound was identified with the help of 13C-NMR, 1H-NMR, HMBC, HMQC, NOESY and COSY. The plant crude
methanol extract showed a significant antispasmodic action on rabbit jejunum and abolished the tissue
contraction completely at concentration of 5.0 mg/ml.
Conclusion: The study concludes that the methanol crude extract of aerial parts of M. africana has antispasmodic
action possibly through the calcium channel blocking mechanisms. A new compound Myrsigenin was isolated
from the EtOAc fraction of the plant.
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