原创力文档antiproliferative effect of methanolic extraction of tualang honey on human keloid fibroblasts抗增殖效果methanolic tualang蜂蜜对人体瘢痕疙瘩成纤维细胞的提取.pdfVIP
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antiproliferative effect of methanolic extraction of tualang honey on human keloid fibroblasts抗增殖效果methanolic tualang蜂蜜对人体瘢痕疙瘩成纤维细胞的提取
Nurul Syazana et al. BMC Complementary and Alternative Medicine 2011, 11:82
/1472-6882/11/82
RESEARCH ARTICLE Open Access
Antiproliferative effect of methanolic extraction
of tualang honey on human keloid fibroblasts
1 1* 2 3
Mohamad Shah Nurul Syazana , Ahmad Sukari Halim , Siew Hua Gan and Shaharum Shamsuddin
Abstract
Background: Keloid is a type of scar which extends beyond the boundaries of the original wound. It can spread
to the surrounding skin by invasion. The use of Tualang honey is a possible approach for keloid treatment. The
objective of this study was to determine the antiproliferative effect of methanolic extraction of Tualang honey to
primary human keloid fibroblasts and to identify the volatile compounds in methanol extraction of Tualang honey.
Methods: Crude Tualang honey was extracted with methanol and then dried using rota vapor to remove
remaining methanol from honey. Normal and keloid fibroblasts were verified and treated with the extracted honey.
Cell proliferation was tested with [3-(4,5-dimethylthiazol-2-yi)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-
tetrazolium, inner salt] (MTS) assay. Extraction of Tualang honey using methanol was carried out and the extracted
samples were analysed using gas chromatography-mass spectrometry (GC-MS). The result was analysed using SPSS
and tested with Kruskal-Wallis and Mann-Whitney tests.
Results: Methanolic extraction of honey has positive anti proliferative effect on keloid fibroblasts in a dose-
dependent manner. The presence of fatty acids such as palmitic acid, stearic acid, oleic acid, linoleic acid and
octadecanoic acid may contribute to the anti-proliferative effect in keloid fibroblasts.
Conclusions:
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