原创力文档association between polymorphisms in the adiponectin gene and cardiovascular disease a meta-analysis脂联素基因的多态性和心血管疾病之间的关联分析.pdfVIP
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association between polymorphisms in the adiponectin gene and cardiovascular disease a meta-analysis脂联素基因的多态性和心血管疾病之间的关联分析
Zhang et al. BMC Medical Genetics 2012, 13:40
/1471-2350/13/40
RESEARCH ARTICLE Open Access
Association between polymorphisms in the
adiponectin gene and cardiovascular disease: a
meta-analysis
*
Huan Zhang, Xingbo Mo, Yongchen Hao and Dongfeng Gu
Abstract
Background: Previous studies have examined the associations between polymorphisms of adiponectin gene
(ADIPOQ) and cardiovascular disease (CVD), but those studies have been inconclusive. The aim of this study was to
access the relationship between three single nucleotide polymorphisms (SNPs), +45 T G (rs2241766), +276 G T
(rs1501299) and -11377 C G (rs266729) in ADIPOQ and CVD.
Methods: A comprehensive search was conducted to identify all studies on the association of ADIPOQ gene
polymorphisms with CVD risk. The fixed and random effect pooled measures (i.e. odds ratio (OR) and 95%
confidence interval (CI)) were calculated in the meta-analysis. Heterogeneity among studies was evaluated using Q
test and the I2. Publication bias was estimated using modified Egger’s linear regression test.
Results: Thirty-seven studies concerning the associations between the three polymorphisms of ADIPOQ gene and
CVD risk were enrolled in this meta-analysis, including 6,398 cases and 10,829 controls for rs2241766, 8,392 cases
and 18,730 controls for rs1501299 and 7,835 cases and 14,023 controls for rs266729. The three SNPs were
significantly associated with CVD, yielding pooled ORs of 1.22 (95%CI: 1.07, 1.39; P = 0.004), 0.90 (95%CI: 0.83, 0.97;
P = 0.007) and 1.09(95%CI: 1.01, 1.17; P = 0.032) for rs2241766, rs1501299 and rs266729, respectively. Rs2241766 and
rs1501299 were significantly associated with coronary heart disease (CHD), yielding pooled ORs of 1.29 (95%CI: 1.09,
1.52; P = 0.004) and 0.89 (
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