association between runx3 promoter methylation and gastric cancer a meta-analysisrunx3启动子甲基化与胃癌之间的联系一个荟萃分析.pdfVIP

Fan et al. BMC Gastroenterology 2011, 11:92 /1471-230X/11/92 RESEARCH ARTICLE Open Access Association between RUNX3 promoter methylation and gastric cancer: a meta-analysis 1 2† 1 1 1 1 1 Xiao-yuan Fan , Xin-lei Hu , Tie-mei Han , Na-na Wang , Yi-miao Zhu , Wen Hu , Zhen-hua Ma , 1 3 4 5 1* Chen-jing Zhang , Xiang Xu , Zai-yuan Ye , Chun-mao Han and Wen-sheng Pan Abstract Background: Runt-related transcription factor 3 (RUNX3) is a member of the runt-domain family of transcription factors and has been reported to be a candidate tumor suppressor in gastric cancer. However, the association between RUNX3 promoter methylation and gastric cancer remains unclear. Methods: We systematically reviewed studies of RUNX3 promoter methylation and gastric cancer published in English or Chinese from January 2000 to January 2011, and quantified the association between RUNX3 promoter methylation and gastric cancer using meta-analysis methods. Results: A total of 1740 samples in 974 participants from seventeen studies were included in the meta-analysis. A significant association was observed between RUNX3 promoter methylation and gastric cancer, with an aggregated odds ratio (OR) of 5.63 (95%CI 3.15, 10.07). There was obvious heterogeneity among studies. Subgroup analyses (including by tissue origin, country and age), meta-regression were performed to determine the source of the heterogeneity. Meta-regression showed that the trend in ORs was inversely correlated with age. No publication bias was detected. The ORs for RUNX3 methylation in well-differentiated vs undifferentiated gastric cancers, and in intestinal-type