association of 25-hydroxyvitamin d deficiency with nt-pro bnp levels in patients with acute myocardial infarction a cross-sectional analysis协会的人体内25 -羟维生素d缺乏与nt-pro bnp水平在急性心肌梗死患者的横断面分析.pdfVIP

Wetmore et al. BMC Research Notes 2011, 4:542 /1756-0500/4/542 RESEARCH ARTICLE Open Access Association of 25-hydroxyvitamin D deficiency with NT-pro BNP levels in patients with acute myocardial infarction: a cross-sectional analysis 1,2,3* 1 4 4 4 4 James B Wetmore , Rajyalakshmi Gadi , John H Lee , James H O’Keefe , Paul S Chan , Fengming Tang and John A Spertus4 Abstract Background: Nutritional vitamin D deficiency is an emerging risk factor for acute myocardial infarction (AMI) and heart failure. The association of 25-hydroxyvitamin D levels with N-terminal pro B-type natriuretic peptide (NT- proBNP), a robust prognostic marker for post-AMI mortality and heart failure, is unknown and could illuminate a potential pathway for adverse outcomes among post-AMI patients with 25-hydroxyvitamin D deficiency. Methods: In a cross-sectional analysis, we studied 238 AMI patients from 21 U.S. centers to test the association of nutritional vitamin D (25-hydroxyvitamin D [25(OH)D]) deficiency with NT-proBNP levels. Levels of 25(OH)D levels were categorized as normal (≥30 ng/mL), insufficient (20 - 30 ng/mL), deficient (10 - ≤20 ng/mL), or severely deficient (≤10 ng/mL). Results: Low 25(OH)D levels were found in 95.7% of AMI patients. No significant trends for higher mean baseline log NT-proBNP levels in severely deficient (6.9 ± 1.3 pg/mL), deficient (6.9 ± 1.2 pg/mL), and insufficient (6.9 ± 0.9 pg/ml) groups were observed as compared with patients having normal (6.1 ± 1.7 pg/mL) levels, P = 0.17. Findings were similar in the subset of patients who had follow-up NT-proBNP levels drawn at one month. In multivariate regression modeling, after adjusting for multiple covariates, 25(OH)