association of adipor2 gene variants with cardiovascular disease and type 2 diabetes risk in individuals with impaired glucose tolerance the finnish diabetes prevention study协会adipor2基因变异与心血管疾病和2型糖尿病的风险患者葡萄糖耐量芬兰糖尿病预防研究.pdfVIP

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association of adipor2 gene variants with cardiovascular disease and type 2 diabetes risk in individuals with impaired glucose tolerance the finnish diabetes prevention study协会adipor2基因变异与心血管疾病和2型糖尿病的风险患者葡萄糖耐量芬兰糖尿病预防研究.pdf

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association of adipor2 gene variants with cardiovascular disease and type 2 diabetes risk in individuals with impaired glucose tolerance the finnish diabetes prevention study协会adipor2基因变异与心血管疾病和2型糖尿病的风险患者葡萄糖耐量芬兰糖尿病预防研究

Siitonen et al. Cardiovascular Diabetology 2011, 10:83 CARDIO /content/10/1/83 VASCULAR DIABETOLOGY ORIGINAL INVESTIGATION Open Access Association of ADIPOR2 gene variants with cardiovascular disease and type 2 diabetes risk in individuals with impaired glucose tolerance: the Finnish Diabetes Prevention Study 1* 1 2,3 1 1,4 Niina Siitonen , Leena Pulkkinen , Jaana Lindström , Marjukka Kolehmainen , Ursula Schwab , Johan G Eriksson2,5,6,7,8, Pirjo Ilanne-Parikka9,10, Sirkka Keinänen-Kiukaanniemi11,12,13, Jaakko Tuomilehto2,3,14,15 and Matti Uusitupa1,16 Abstract Background: Adiponectin is an adipokine with insulin-sensitising and anti-atherogenic effects. Two receptors for adiponectin, ADIPOR1 and ADIPOR2, have been characterized that mediate effects of adiponectin in various tissues. We examined whether genetic variation in ADIPOR2 predicts the development of cardiovascular disease (CVD) and/ or Type 2 Diabetes (T2DM) in individuals with impaired glucose tolerance (IGT) participating the Finnish Diabetes Prevention Study (DPS). Methods: CVD morbidity and mortality data were collected during a median follow-up of 10.2 years (range 1-13 years) and conversion from IGT to T2DM was assessed during a median follow-up of 7 years (range 1-11 years). Altogether eight SNPs in the ADIPOR2 locus were genotyped in 484 participants of the DPS. Moreover, the same SNPs were genotyped and the mRNA expression levels of ADIPOR2 were determined