association of a functional microsatellite within intron 1 of the bmp5 gene with susceptibility to osteoarthritis协会的一个功能性微卫星基因内区1内bmp5基因对骨关节炎.pdfVIP
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BMC Medical Genetics BioMed Central
Research article Open Access
Association of a functional microsatellite within intron 1 of the
BMP5 gene with susceptibility to osteoarthritis
1 1 1 1
James M Wilkins* , Lorraine Southam , Zehra Mustafa , Kay Chapman and
John Loughlin2
Address: 1University of Oxford, Institute of Musculoskeletal Sciences, Botnar Research Centre, Nuffield Orthopaedic Centre, Oxford, OX3 7LD, UK
and 2Newcastle University, Institute of Cellular Medicine, Newcastle-upon-Tyne, NE2 4HH, UK
Email: James M Wilkins* - james_wilkins@; Lorraine Southam - lorraine.southam@ndos.ox.ac.uk;
Zehra Mustafa - zehra.mustafa@ndos.ox.ac.uk; Kay Chapman - kay@well.ox.ac.uk; John Loughlin - john.loughlin@ncl.ac.uk
* Corresponding author
Published: 19 December 2009 Received: 7 August 2009
Accepted: 19 December 2009
BMC Medical Genetics 2009, 10:141 doi:10.1186/1471-2350-10-141
This article is available from: /1471-2350/10/141
© 2009 Wilkins et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: In a previous study carried out by our group, the genotyping of 36 microsatellite
markers from within a narrow interval of chromosome 6p12.3-q13 generated evidence for linkage
and for associa
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