association of an insig2 obesity allele with cardiovascular phenotypes is gender and age dependent协会insig2仅肥胖的等位基因与心血管疾病表型性别和年龄相关的.pdfVIP

Skelding et al. BMC Cardiovascular Disorders 2010, 10:46 /1471-2261/10/46 RESEARCH ARTICLE Open Access Association of an INSIG2 obesity allele with cardiovascular phenotypes is gender and age dependent 1* 1 2 2 2 1 1 Kimberly A Skelding , Glenn S Gerhard , Helen Vlachos , Faith Selzer , Sheryl F Kelsey , Xin Chu , Robert Erdman , David O Williams3, Kevin E Kip4 Abstract Background: The INSIG2 gene has been implicated in cholesterol metabolism and a single nucleotide polymorphism (SNP) near INSIG2 has been shown to be associated with obesity. We sought to determine the relationship of the INSIG2 SNP to cardiovascular disease (CVD) related phenotypes. Methods and Results: Nine hundred forty six patients undergoing percutaneous coronary intervention (PCI) in wave 5 of the multicenter NHLBI Dynamic Registry were genotyped using RT-PCR/TaqMan/allelic discrimination for the rs7566605 SNP near the INSIG2 gene. Clinical variables analyzed include demographics, medical history, and procedural details. The prevalence of peripheral vascular disease (PVD) was significantly higher in older men (≥65 years) who were either homozygous or carriers of the obesity/lipid risk allele (C”) compared to non-carriers (odds ratio 3.4, p = 0.013) using a logistic regression model incorporating history of hypercholesterolemia, history of hypertension, cerebrovascular disease, history of diabetes, and BMI. A similar relationship with cerebrovascular disease was found in older (65) women (odds ratio 3.4, p = 0.013). The INSIG2 SNP was not associated with BMI, nor with other clinical variables. Conclusion: Age and gender may influence the association of the INSIG2 obesity SNP with PVD and cerebrovascular disease