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association of cd69 up-regulation on cd4+ cla+ t cells versus patch test, strip patch test and clinical history in nickel sensitization协会cd69上调对cd4 + cla + t细胞与补丁测试,带斑贴试验和临床历史镍致敏.pdfVIP

association of cd69 up-regulation on cd4+ cla+ t cells versus patch test, strip patch test and clinical history in nickel sensitization协会cd69上调对cd4 + cla + t细胞与补丁测试,带斑贴试验和临床历史镍致敏.pdf

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associationofcd69up-regulationoncd4clatcellsversuspatchtest,strippatchtestandclinicalhistoryinnickelsensitization协会cd69上调对cd4clat细胞与补丁测试,带斑贴试验和临床历史镍致敏

J uly 26, 2010 U Ro P An J oUR nAl of M D I cAl R s ARcH 303 ur J Med Res (2010) 15: 303-308 © I. Holzapfel Publishers 2010 AssocIAtIon of cD69 UP-R gUlAtIon on cD4+ clA + t c lls V RsUs PAtcH t st, stRIP PAtcH t st AnD clInIcAl HIstoRy In nIck l s nsItIzAtIon 1 2 1 1 1 H. Dickel , o. kuss , J. kamphowe , P. Altmeyer , s. Höxtermann 1Department of Dermatology and Allergology, Ruhr University Bochum, Bochum, germany, 2Institute of Medical pidemiology, Biostatistics, and Informatics, Martin luther University of Halle-Wittenberg, Halle (saale) , germany Abstract eral blood mononuclear cells; PHA-P = Phytohemag- Obj ecti ve: the patch test (Pt) with its modification – glutinin; Pt = Patch test; Roc = Receiver operating the strip patch test (sPt) – is the standard in vivo pro- characteristic; sPt = strip patch test cedure to diagnose an allergic contact dermatitis (AcD) . to date, none of the in vitro tests for the diag- IntRoDUctIon nosis of AcD fulfils the requirements of an easy, valid and reliable test. to investigate the prediction ability of since its inauguration in 1895 by J adassohn [1], the a flow cytometric assay of cD69 up-regulation on patch test (Pt) is believed to be th

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