association of glycemic variability and the presence and severity of coronary artery disease in patients with type 2 diabetes血糖变异性和协会的存在和严重性在2型糖尿病患者冠状动脉疾病.pdfVIP

Su et al. Cardiovascular Diabetology 2011, 10:19 CARDIO /content/10/1/19 VASCULAR DIABETOLOGY ORIGINAL INVESTIGATION Open Access Association of glycemic variability and the presence and severity of coronary artery disease in patients with type 2 diabetes 1 1 1 2 1 1 1 1* Gong Su , Shuhua Mi , Hong Tao , Zhao Li , Hongxia Yang , Hong Zheng , Yun Zhou , Changsheng Ma Abstract Background: Glucose variability is one of components of the dysglycemia in diabetes and may play an important role in development of diabetic vascular complications. The objective of this study was to assess the relationship between glycemic variability determined by a continuous glucose monitoring (CGM) system and the presence and severity of coronary artery disease (CAD) in patients with type 2 diabetes mellitus (T2DM). Methods: In 344 T2DM patients with chest pain, coronary angiography revealed CAD (coronary stenosis ≥ 50% luminal diameter narrowing) in 252 patients and 92 patients without CAD. Gensini score was used to assess the severity of CAD. All participants’ CGM parameters and biochemical characteristics were measured at baseline. Results: Diabetic patients with CAD were older, and more were male and cigarette smokers compared with the controls. Levels of the mean amplitude of glycemic excursions (MAGE) (3.7 ± 1.4 mmol/L vs. 3.2 ± 1.2 mmol/L, p 0.001), postprandial glucose excursion (PPGE) (3.9 ± 1.6 mmol/L vs. 3.6 ± 1.4 mmol/L, p = 0.036), serum high- sensitive C-reac