association of iron overload based quantitative t2 mri technique and carotid intima-media thickness in patients with beta-thalassemia a cross-sectional study基于铁过载量化t2 mri技术协会和患者颈动脉内膜中层厚度beta-thalassemia横断面研究.pdfVIP

下载本文档

1
0
约3.87万字
约 6页
2017-10-14 发布于上海
举报
版权申诉

association of iron overload based quantitative t2 mri technique and carotid intima-media thickness in patients with beta-thalassemia a cross-sectional study基于铁过载量化t2 mri技术协会和患者颈动脉内膜中层厚度beta-thalassemia横断面研究.pdf

1、本文档共6页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

association of iron overload based quantitative t2 mri technique and carotid intima-media thickness in patients with beta-thalassemia a cross-sectional study基于铁过载量化t2 mri技术协会和患者颈动脉内膜中层厚度beta-thalassemia横断面研究

Akhlaghpoor et al. BMC Cardiovascular Disorders 2010, 10:62 /1471-2261/10/62 RESEARCH ARTICLE Open Access Association of iron overload based quantitative T2* MRI technique and carotid intima-media thickness in patients with beta-thalassemia: A cross-sectional study Shahram Akhlaghpoor1*, Morteza Hoseini2†, Amirhosein Jafarisepehr2† Abstract Background: Body iron status has been implicated in atherosclerotic cardiovascular disease. The main hypothesis is that high iron status is associated with increased risk of atherosclerosis. We investigated the potential role of iron as an additional risk factor promoting atherosclerosis among beta-thalassemic patients. Methods: In this cross-sectional study, the liver iron load was assessed by quantitative T2* MRI technique and intima-media thickness (IMT) of the common carotid artery by high-resolution ultrasound among 119 patients (62 male, 57 female) with beta-thalassemia (major and intermediate) whose age ranged from 10 to 50 years with a mean of 25.6 years. The patients were divided into three groups according to the severity of iron loading, obtained by T2*MRI technique: group I (normal), group II (mild) and group III (moderate and severe) iron load. For elimination of the effect of age on carotid IMT values, the patients also were divided into four age groups (10-19 y, 20-29 y, 30-39 y and 40-50 y). Mean carotid IMT based on the severity of iron loading were compared at different age groups, using one way ANOVA analysis for assessing the effect of iron loading on carotid IMT. Pearson’s coefficient of correlation were used to assess the degree of correlation between studied variables (liver T2*, IMT, age). Results: There were significant differences in mean carotid IMT based on the severity of iron loading at different age groups, with P = 0.003 at 20-29 y, P = 0.006 a