原创力文档associations of sex hormone-binding globulin and testosterone with diabetes among men and women (the saku diabetes study) a case control study协会与糖尿病性hormone-binding球蛋白和睾酮在男性和女性(saku糖尿病研究)病例对照研究.pdfVIP
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associations of sex hormone-binding globulin and testosterone with diabetes among men and women (the saku diabetes study) a case control study协会与糖尿病性hormone-binding球蛋白和睾酮在男性和女性(saku糖尿病研究)病例对照研究
Goto et al. Cardiovascular Diabetology 2012, 11:130 CARDIO
/content/11/1/130 VASCULAR
DIABETOLOGY
ORIGINAL INVESTIGATION Open Access
Associations of sex hormone-binding globulin
and testosterone with diabetes among men and
women (the Saku Diabetes study): a case control
study
1,2,4 2,3 1,2,4 5 2 6 4
Atsushi Goto , Akemi Morita , Maki Goto , Satoshi Sasaki , Motohiko Miyachi , Naomi Aiba , Yasuo Terauchi ,
Mitsuhiko Noda1,7,8*, Shaw Watanabe2 for the Saku Cohort Study Group
Abstract
Background: Sex hormone-binding globulin (SHBG) levels and sex hormones have been implicated in the
pathogenesis of type 2 diabetes and cardiovascular diseases. As fatty liver has been suggested to be a major
determinant of SHBG levels, we examined whether the associations of SHBG and testosterone with diabetes were
independent of fatty liver.
Methods: We conducted a case–control study that included 300 diabetes cases (215 men and 85 women) and
300 matched controls from the Saku cohort study. Diabetes was defined by either fasting plasma glucose levels
≥126 mg/dL, 2-h post-load glucose levels ≥200 mg/dL after a 75 g oral glucose tolerance test, or diabetes
diagnosed by physicians. We fitted conditional logistic regression models to examine the associations between
SHBG and total testosterone levels with diabetes by sex. To evaluate the impact of fatty liver, we used the fatty liver
index (FLI), a validated measure derived from serum triglyceride level
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