asymmetrical distribution of non-conserved regulatory sequences at phox2b is reflected at the encode loci and illuminates a possible genome-wide trendnon-conserved监管序列的不对称分布在phox2b反映编码基因座和照明可能全基因组的趋势.pdfVIP

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asymmetrical distribution of non-conserved regulatory sequences at phox2b is reflected at the encode loci and illuminates a possible genome-wide trendnon-conserved监管序列的不对称分布在phox2b反映编码基因座和照明可能全基因组的趋势.pdf

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asymmetrical distribution of non-conserved regulatory sequences at phox2b is reflected at the encode loci and illuminates a possible genome-wide trendnon-conserved监管序列的不对称分布在phox2b反映编码基因座和照明可能全基因组的趋势

BMC Genomics BioMed Central Research article Open Access Asymmetrical distribution of non-conserved regulatory sequences at PHOX2B is reflected at the ENCODE loci and illuminates a possible genome-wide trend †1 †1 1 1 David M McGaughey , Zachary E Stine , Jimmy L Huynh , Ryan M Vinton and Andrew S McCallion*1,2 Address: 1McKusick – Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, 733 N. Broadway, BRB Suite 449, Baltimore, MD 21205, USA and 2Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA Email: David M McGaughey - davidm@; Zachary E Stine - zstine1@; Jimmy L Huynh - jimh@; Ryan M Vinton - rvinton1@; Andrew S McCallion* - andy@ * Corresponding author †Equal contributors Published: 7 January 2009 Received: 8 July 2008 Accepted: 7 January 2009 BMC Genomics 2009, 10:8 doi:10.1186/1471-2164-10-8 This article is available from: /1471-2164/10/8 © 2009 McGaughey et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Transcriptional regulatory elements are central to development and interspecific phenotyp