atherosclerosis in young brazilians suffering violent deaths a pathological study动脉粥样硬化在年轻的巴西人遭受暴力死亡的病理研究.pdfVIP

Modelli et al. BMC Research Notes 2011, 4:531 /1756-0500/4/531 RESEARCH ARTICLE Open Access Atherosclerosis in young Brazilians suffering violent deaths: a pathological study 1,2* 2 1 1 Manoel ES Modelli , Áurea S Cherulli , Lenora Gandolfi and Riccardo Pratesi Abstract Background: Atherosclerosis is the leading cause of coronary heart disease and ischemic stroke, which can cause sudden death in adulthood. In general, the clinical manifestations of cardiovascular diseases are caused by atherosclerosis, which is a process that starts during middle age. More recent studies indicate that the atherosclerotic process begins during childhood. Methods: To evaluate the extent of atherosclerotic disease in young Brazilians, we conducted a study of the pathological alterations in the major arteries of victims of violent death. Samples of the right carotid artery, left coronary artery, and thoracic aorta of young victims of violent death were analyzed and graded in accordance with the histological atherosclerotic lesion types proposed by the American Heart Association. Samples were collected from 100 individuals who had died from external causes, aged from 12 to 33 years. Results: The majority of cases (83%) were male, and 66% of deaths were homicides caused by firearms. The median age was 20.0 years and mean body mass index was 20.9 kg/m2. Of the right carotid artery specimens, 3% were normal, 55% had type I, 40% had type II, 1% had type III, and 1% had type IV atherosclerotic lesions. Of the left coronary artery specimens, 5% were normal, 48% had type I, 41% had type II, 3% had type III, and 3% had type IV lesions. Of the thoracic aorta specimens, none were normal, 13% had type I, 64% had type II, 22% had type III, an