原创力文档athe dyslexia candidate gene dyx1c1 is a potential marker of poor survival in breast cancer雅典诵读困难dyx1c1候选基因是一个贫穷的生存在乳腺癌的潜在标志物.pdfVIP
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athe dyslexia candidate gene dyx1c1 is a potential marker of poor survival in breast cancer雅典诵读困难dyx1c1候选基因是一个贫穷的生存在乳腺癌的潜在标志物
Rosin et al. BMC Cancer 2012, 12:79
/1471-2407/12/79
RESEARCH ARTICLE Open Access
The dyslexia candidate gene DYX1C1 is a
potential marker of poor survival in breast cancer
1* 2 3 2 3 3† 1,4,5†
Gustaf Rosin , Ulf Hannelius , Linda Lindström , Per Hall , Jonas Bergh , Johan Hartman and Juha Kere
Abstract
Background: The dyslexia candidate gene, DYX1C1, shown to regulate and interact with estrogen receptors and
involved in the regulation of neuronal migration, has recently been proposed as a putative cancer biomarker. This
study was undertaken to assess the prognostic value and therapy-predictive potential of DYX1C1 mRNA and
protein expression in breast cancer.
Methods: DYX1C1 mRNA expression was assessed at the mRNA level in three independent population-derived
patient cohorts. An association to estrogen/progesterone receptor status, Elston grade, gene expression subtype
and lymph node status was analyzed within these cohorts. DYX1C1 protein expression was examined using
immunohistochemistry in cancer and normal breast tissue. The statistical analyses were performed using the non-
parametric Wilcoxon rank-sum test, ANOVA, Fisher’s exact test and a multivariate proportional hazard (Cox) model.
Results: DYX1C1 mRNA is significantly more highly expressed in tumors that have been classified as estrogen
receptor a and progesterone receptor-positive. The expression of DYX1C1 among the molecular subtypes shows
the lowest median expression within the basal type tumors, which are considered to have the worst prognosis.
The expression of DYX1C1 is significantly lower in tumors graded as Elston grade 3 compared with grades 1 and 2.
DYX1C1 protein is expressed in 88% of tumors and in all
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