原创力文档assessment of leukemia inhibitory factor and glycoprotein 130 expression in endometrium and uterine flushing a possible diagnostic tool for impaired fertility白血病抑制因子和糖蛋白130表达在子宫内膜和子宫冲洗生育能力受损的可能的诊断工具.pdfVIP
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assessment of leukemia inhibitory factor and glycoprotein 130 expression in endometrium and uterine flushing a possible diagnostic tool for impaired fertility白血病抑制因子和糖蛋白130表达在子宫内膜和子宫冲洗生育能力受损的可能的诊断工具
Tawfeek et al. BMC Womens Health 2012, 12:10
/1472-6874/12/10
RESEARCH ARTICLE Open Access
Assessment of leukemia inhibitory factor and
glycoprotein 130 expression in endometrium and
uterine flushing: a possible diagnostic tool for
impaired fertility
1 1* 2 3 1
Manal A Tawfeek , Manal A Eid , Azza M Hasan , Manal Mostafa and Hesham A El-Serogy
Abstract
Background: Uterine receptivity and implantation are complex processes requiring coordinated expression of
molecules by zygote and uterus. Our objective was to evaluate the role of the endometrial expression of leukemia
inhibitory factor (LIF) and its glycoprotein 130 (gp130) receptor molecules and their secretion in uterine flushing
during the window of implantation in cases of primary unexplained infertility
Case presentation: The study was conducted on 25 infertile women with unexplained infertility for at least two
years and 10 normal fertile women as a control group . Endometrial tissue and uterine flushing were obtained. Each
tissue specimen was divided into two pieces; one piece was used for histological dating of the endometrium and
for immunostaining of progesterone receptors, and the second was used for RNA extraction and PCR assay of LIF
and gp130 mRNA expression. Serum estrogen and progesterone were measured for all subjects. LIF mRNA was
expressed in the endometrium of all normal fertile women but significantly decreased in infertile women. LIF was
not detectable in 88% of infertile women while it was fairly detectable in 12% of them. Gp130 mRNA was hardly
detectable in both fertile and infertile women with no difference between them. Infertile women secreted
significantly less LIF and gp130 molecules in the uterine flushing compared wit
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