原创力文档autocorrelation analysis reveals widespread spatial biases in microarray experiments自相关分析显示广泛的空间偏见在微阵列实验中.pdfVIP
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autocorrelation analysis reveals widespread spatial biases in microarray experiments自相关分析显示广泛的空间偏见在微阵列实验中
BMC Genomics BioMed Central
Research article Open Access
Autocorrelation analysis reveals widespread spatial biases in
microarray experiments
1 1 1,2
Amnon Koren , Itay Tirosh and Naama Barkai*
Address: 1Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel and 2Department of Physics of Complex
Systems, Weizmann Institute of Science, Rehovot 76100, Israel
Email: Amnon Koren - amnon.koren@weizmann.ac.il; Itay Tirosh - itay.tirosh@weizmann.ac.il;
Naama Barkai* - naama.barkai@weizmann.ac.il
* Corresponding author
Published: 12 June 2007 Received: 12 February 2007
Accepted: 12 June 2007
BMC Genomics 2007, 8:164 doi:10.1186/1471-2164-8-164
This article is available from: /1471-2164/8/164
© 2007 Koren et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: DNA microarrays provide the ability to interrogate multiple genes in a single
experiment and have revolutionized genomic research. However, the microarray technology
suffers from various forms of biases and relatively low reproducibility. A particular source of false
data has been described, in which non-random placement of gene probes on the microa
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