原创力文档association of plasminogen activator inhibitor-1 and tissue plasminogen activator with type 2 diabetes and metabolic syndrome in malaysian subjects纤溶酶原激活物inhibitor-1协会和组织纤溶酶原激活物与2型糖尿病和代谢综合征在马来西亚.pdfVIP
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association of plasminogen activator inhibitor-1 and tissue plasminogen activator with type 2 diabetes and metabolic syndrome in malaysian subjects纤溶酶原激活物inhibitor-1协会和组织纤溶酶原激活物与2型糖尿病和代谢综合征在马来西亚
Al-Hamodi et al. Cardiovascular Diabetology 2011, 10:23 CARDIO
/content/10/1/23 VASCULAR
DIABETOLOGY
ORIGINAL INVESTIGATION Open Access
Association of plasminogen activator inhibitor-1
and tissue plasminogen activator with type 2
diabetes and metabolic syndrome in
Malaysian subjects
1* 2 1,3 4 1*
Zaid Al-Hamodi , Ikram S Ismail , Riyadh Saif-Ali , Khaled A Ahmed , Sekaran Muniandy
Abstract
Background: Increased plasma plasminogen activator inhibitor-1 (PAI-1) activity and decreased tissue plasminogen
activator (tPA) activity could be considered a true component of the metabolic syndrome (MetS) associated with
an increased risk of developing cardiovascular diseases (CVD) and fibrinolytic abnormalities. The aim of this study
was to investigate the association of tPA and its inhibitor PAI-1 with type 2 diabetes (T2D) and MetS and
interrelationship between PAI-1and tPA activities and antigens in Malaysian T2D and normal subjects.
Methods: The plasma activities and antigens of PAI-1 and tPA and the levels of the tPA/PAI-1 complex as well as
serum insulin, parameter of the coronary risk panel and plasma glucose at fasting state were studied in 303 T2D
subjects (227 with MetS and 76 without MetS), 131 normal non-diabetic non-metabolic subjects and 101 non-
diabetic MetS subjects.
Results: The PAI-1 activity was higher in subjects with T2D with MetS (P = 9.8 × 10-19) and non-diabetic subjects
with MetS (P = 3.0 × 10-15), whereas the tPA activity was lower in T2D
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