原创力文档association of serum osteoprotegerin with vascular calcification in patients with type 2 diabetes血清osteoprotegerin协会在2型糖尿病患者血管钙化.pdfVIP
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association of serum osteoprotegerin with vascular calcification in patients with type 2 diabetes血清osteoprotegerin协会在2型糖尿病患者血管钙化
Aoki et al. Cardiovascular Diabetology 2013, 12:11 CARDIO
/content/12/1/11 VASCULAR
DIABETOLOGY
ORIGINAL INVESTIGATION Open Access
Association of serum osteoprotegerin with
vascular calcification in patients with type 2
diabetes
Atsushi Aoki, Miho Murata, Tomoko Asano, Aki Ikoma, Masami Sasaki, Tomoyuki Saito, Taeko Otani, Sachimi Jinbo,
*
Nahoko Ikeda, Masanobu Kawakami and San-e Ishikawa
Abstract
Background: Osteoprotegerin is a member of the tumor necrosis factor-related family and inhibits RANK
stimulation of osteoclast formation as a soluble decoy receptor. The goal of this study was to determine the
relationship of serum osteoprotegerin with vascular calcification in patients with type 2 diabetes.
Methods: The subjects were 124 patients with type 2 diabetes mellitus, including 88 males and 36 females with a
mean (± SD) age of 65.6 ± 8.2 years old. Serum levels of osteoprotegerin, osteocalcin, fibroblast growth factor 23
(FGF23), 25-hydroxyvitamin D3 and adiponectin were measured by ELISA. Vascular calcification in the cervical artery
was examined by ultrasound sonography. The subjects were divided into 4 quartiles depending on serum
osteoprotegerin levels.
Results: Vascular calcification was significantly higher in the 4th quartile and significantly lower in the 1st quartile
of serum osteoprotegerin levels, compared to other quartiles. There were no differences in serum osteoprotegerin
and vascular calcification among patients with different stages of diabetic nephropathy, but seru
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