association of the maoa promoter uvntr polymorphism with suicide attempts in patients with major depressive disorder协会的maoa发起人uvntr多态性与重度抑郁症患者的自杀企图.pdfVIP

Lung et al. BMC Medical Genetics 2011, 12:74 /1471-2350/12/74 RESEARCH ARTICLE Open Access Association of the MAOA promoter uVNTR polymorphism with suicide attempts in patients with major depressive disorder For-Wey Lung1,2,3, Dong-Sheng Tzeng1,4, Mei-Feng Huang5 and Ming-Been Lee6,7,8* Abstract Background: The MAOA uVNTR polymorphism has been documented to affect the MAOA gene at the transcriptional level and is associated with aggressive impulsive behaviors, depression associated with suicide (depressed suicide), and major depressive disorder (MDD). We hypothesized that the uVNTR polymorphism confers vulnerability to MDD, suicide or both. The aim of this study was to explore the association between the MAOA uVNTR and depressed suicide, using multiple controls. Methods: Four different groups were included: 432 community controls, 385 patients with MDD who had not attempted suicide, 96 community subjects without mental disorders who had attempted suicide, and 109 patients with MDD who had attempted suicide. The MAOA uVNTR polymorphism was genotyped by a PCR technique. The symptom profiles and personal characteristics in each group were also compared. 2 Results: The MAOA 4R allele was more frequent in males with MDD than in male community controls (c = 4.182, p = 0.041). Logistic regression analysis showed that, among the depressed subjects, those younger in age, more neurotic or who smoked had an increased risk of suicide (b = -0.04, p = 0.002; b = 0.15, p = 0.017; b = 0.79, p = 0.031, respectively). Moreover, among those who had attempted suicide, those younger in age, with more paternal overprotection, and more somatic symptoms were more likely to be in the MDD group th