原创力文档association of polymorphisms in survivin gene with the risk of hepatocellular carcinoma in chinese han population a case control study协会的生存素基因多态性与肝细胞癌的风险在中国汉族人群病例对照研究.pdfVIP
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association of polymorphisms in survivin gene with the risk of hepatocellular carcinoma in chinese han population a case control study协会的生存素基因多态性与肝细胞癌的风险在中国汉族人群病例对照研究
Li et al. BMC Medical Genetics 2012, 13:1
/1471-2350/13/1
RESEARCH ARTICLE Open Access
Association of polymorphisms in survivin gene
with the risk of hepatocellular carcinoma in
Chinese han population: a case control study
1,2 1 1 3 1*
Yuhua Li , Jiaofeng Wang , Feng Jiang , Wenyao Lin and Wei Meng
Abstract
Background: Survivin, one of the strongest apoptosis inhibitors, plays a critical role in the development and
progression of hepatocellular carcinoma (HCC). By comparison, relatively little is known about the effect of survivin
gene polymorphisms on HCC susceptibility. Our study aimed to investigate the association of survivin gene
polymorphisms with the risk of HCC in Chinese han population.
Methods: A case-control study was conducted in Chinese han population consisting of 178 HCC cases and 196
cancer-free controls. Information on demographic data and related risk factors was collected for all subjects.
Polymorphisms of the survivin gene, including three loci of rs8073069, rs9904341 and rs1042489, were selected and
genotyped by a polymerase chain reaction- restriction fragment length polymorphism (PCR-RFLP) technique.
Association analysis of genotypes/alleles and haplotypes from these loci with the risk of HCC was conducted under
different genetic models.
Results: Using univariate analysis of rs8073069, rs9904341 and rs1042489 under different genetic models, no
statistically significant difference was found in genotype or allele distribution of HCC cases relative to the controls
(P 0.05). Linkage disequilibrium (LD) analysis showed that these loci were in LD. Multivariate logistic regression
indicated that with no G-C-T haplotype as reference, the haplotype of G-C-T from these loci was associated with a
lower ri
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