原创力文档association of polymorphism of ptpn 11 encoding shp-2 with gastric atrophy but not gastric cancer in helicobacter pylori seropositive chinese population协会的多态性ptpn 11编码shp-2在幽门螺杆菌与胃癌胃萎缩但不是血清反应阳性的中国人口.pdfVIP
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association of polymorphism of ptpn 11 encoding shp-2 with gastric atrophy but not gastric cancer in helicobacter pylori seropositive chinese population协会的多态性ptpn 11编码shp-2在幽门螺杆菌与胃癌胃萎缩但不是血清反应阳性的中国人口
Jiang et al. BMC Gastroenterology 2012, 12:89
/1471-230X/12/89
RESEARCH ARTICLE Open Access
Association of polymorphism of PTPN 11
encoding SHP-2 with gastric atrophy but not
gastric cancer in Helicobacter pylori seropositive
Chinese population
1 1 1 2 2 1 3 3*
Jing Jiang , Zhi-Fang Jia , Fei Kong , Mei-Shan Jin , Yin-Ping Wang , Suyan Tian , Jian Suo and Xueyuan Cao
Abstract
Background: The interaction between Src homology 2 domain-containing protein tyrosine phosphatase (SHP-2) of
gastric epithelial cells and cagA from H. pylori plays a crucial role in developments of gastric atrophy and gastric
cancer. This study aimed to investigate the association of haplotype tagging SNPs (htSNPs) in the PTPN11 gene
encoding SHP-2 with gastric atrophy and gastric cancer in Chinese population.
Methods: The subjects comprised 414 patients with gastric cancer, 109 individuals with gastric atrophy and 923
healthy controls. Blood was collected from October 2008 to October 2010. Five htSNPs rs2301756, r
r rs7958372 and rs4767860 from the PTPN11 gene were selected and genotyped by Taqman assay.
Serum Ig G antibodies to H. pylori were detected by ELISA. Gastric atrophy was screened by the levels of serum
pepsinogenIandII, and confirmed by endoscopy and histopatholgical examinations. Odds ratio (ORs) and 95%
confidence intervals (CIs) were calculated by a multivariate logistic regression.
Results: Among H. pylori seropositive subjects, age and gender-adjusted OR of gastric atrophy was 2.47 (95%CI
1.13-4.55, P = 0.02) for CC genotype compared with CT/TT genotypes, suggesting a recessive model of genetic risk
for r The prevalence of H. pylori seropositivity were signifi
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