e2f1 and p53 transcription factors as accessory factors for nucleotide excision repair转录因子e2f1和p53作为核苷酸切除修复的辅助因素.pdfVIP
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e2f1 and p53 transcription factors as accessory factors for nucleotide excision repair转录因子e2f1和p53作为核苷酸切除修复的辅助因素
Int. J. Mol. Sci. 2012, 13, 13554-13568; doi:10.3390/ijms131013554
OPEN ACCESS
International Journal of
Molecular Sciences
ISSN 1422-0067
/journal/ijms
Review
E2F1 and p53 Transcription Factors as Accessory Factors for
Nucleotide Excision Repair
Renier Vélez-Cruz and David G. Johnson *
Department of Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center,
Science Park, 1801 Park Road 1C, Smithville, TX 78957, USA; E-Mail: rvelez@
* Author to whom correspondence should be addressed; E-Mail: djohnson@;
Tel.: +1-512-237-9511; Fax: +1-512-237-6533.
Received: 17 August 2012; in revised form: 10 October 2012 / Accepted: 15 October 2012 /
Published: 19 October 2012
Abstract: Many of the biochemical details of nucleotide excision repair (NER) have been
established using purified proteins and DNA substrates. In cells however, DNA is tightly
packaged around histones and other chromatin-associated proteins, which can be an
obstacle to efficient repair. Several cooperating mechanisms enhance the efficiency of
NER by altering chromatin structure. Interestingly, many of the players involved in
modifying chromatin at sites of DNA damage were originally identified as regulators of
transcription. These include ATP-dependent chromatin remodelers, histone modifying
enzymes and several transcription factors. The p53 and E2F1 transcription factors are wel
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