epidemic spread of st1-mrsa-iva in a neonatal intensive care unit, italy流行病的传播st1-mrsa-iva在新生儿重症监护室,意大利.pdfVIP

Giuffrè et al. BMC Pediatrics 2012, 12:64 /1471-2431/12/64 RESEARCH ARTICLE Open Access Epidemic spread of ST1-MRSA-IVa in a neonatal intensive care unit, Italy 1 1 2 2,3 2 1 Mario Giuffrè , Domenico Cipolla , Celestino Bonura , Daniela Maria Geraci , Aurora Aleo , Stefania Di Noto , 1 1 2* Federica Nociforo , Giovanni Corsello and Caterina Mammina Abstract Background: Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has recently emerged as an important pathogen in neonatal intensive care units (NICUs). The purposes of this study were to characterize methicillin-resistant isolates from an outbreak in a NICU, to examine the genetic traits and clonality of CA-MRSA, and to review the characteristics and outcomes of the neonatal cases and investigate the routes of entry and transmission of the MRSA outbreak strain in the NICU under study. Methods: The study NICU practiced an active surveillance program for multidrug-resistant organisms, including weekly cultures for detection of MRSA from nasal swabs among all the admitted neonates. All first isolates from surveillance cultures and all clinical isolates were submitted for susceptibility testing and genotyping. Data from each infant’s medical records were prospectively included in a database, and the clinical features and outcomes of the colonized/infected infants were assessed. Results: A total of 14 infants were colonized or infected by a strain of ST1-MRSA-IVa between April and August 2011. The CA-MRSA strain appeared to have been introduced to the NICU by an infected infant transferred from another hospital. The o