histopathological placental lesions in mild gestational hyperglycemic and diabetic women组织病理学胎盘病变轻度妊娠高血糖的糖尿病妇女.pdfVIP

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histopathological placental lesions in mild gestational hyperglycemic and diabetic women组织病理学胎盘病变轻度妊娠高血糖的糖尿病妇女.pdf

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histopathological placental lesions in mild gestational hyperglycemic and diabetic women组织病理学胎盘病变轻度妊娠高血糖的糖尿病妇女

Rudge et al. Diabetology Metabolic Syndrome 2011, 3:19 DIABETOLOGY /content/3/1/19 METABOLIC SYNDROME RESEARCH Open Access Histopathological placental lesions in mild gestational hyperglycemic and diabetic women 1* 2 1 1 2 1 Marilza VC Rudge , César P Lima , Débora C Damasceno , Yuri K Sinzato , Gustavo Napoli , Cibele VC Rudge , Franciane Q Gallego1 and Iracema MP Calderon1 Abstract Objective: To investigate and compare the incidence of histopathological placental lesions in mild gestational hyperglycemia, gestational diabetes and overt diabetes at term and preterm gestation. Research design and methods: One-hundred-and-thirty-one placental samples were collected from Diabetes mellitus (DM) positive screened patients. Two diagnostic tests, glycemic profile and 100 g oral glucose tolerance test (OGTT) in parallel identified 4 groups normoglycemic, mild gestational hyperglycemia (MGH), gestational DM (GDM) or overt DM (DM). Placental tissue specimens and sections from 4 groups were obtained by uniform random sampling and stained with hematoxylin-eosin. Results: Placentas from MGH group presented 17 types of histopathological change and higher rates of syncytial nodes and endarteritis. GDM placentas presented only nine types of histopathological change, high rates of dysmaturity, low rates of calcification and no syncytial nodes. Overt DM placentas showed 22 types of histopathological change, 21 of which were present in the preterm period. There were histopathological similari