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monitoring healthy metabolic trajectories with nutritional metabonomics监测健康与营养代谢组学代谢轨迹.pdf

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monitoring healthy metabolic trajectories with nutritional metabonomics监测健康与营养代谢组学代谢轨迹

Nutrients 2009, 1, 101-110; doi:10.3390/nu1010101 OPEN ACCESS nutrients ISSN 2072-6643 /journal/nutrients Review Monitoring Healthy Metabolic Trajectories with Nutritional Metabonomics Sebastiano Collino, François-Pierre J. Martin, Sunil Kochhar and Serge Rezzi * BioAnalytical Science, Metabonomics Biomarkers, Nestlé Research Center, PO Box 44, CH-1000 Lausanne 26, Switzerland; E-Mails: Sebastiano.Collino@ (S.C.); Francois-Pierre.Martin@ (F.P.J.M.); Sunil.Kochhar@ (S.K.) * Author to whom correspondence should be addressed: E-Mail: Serge.Rezzi@. Received: 3 August 2009 / Accepted: 31 August 2009 / Published: 4 September 2009 Abstract: Metabonomics is a well established analytical approach for the analysis of physiological regulatory processes via the metabolic profiling of biofluids and tissues in living organisms. Its potential is fully exploited in the field of “nutrimetabonomics” that aims at assessing the metabolic effects of active ingredients and foods in individuals. Yet, one of the greatest challenges in nutrition research is to decipher the critical interactions between mammalian organisms and environmental factors, including the gut microbiota. “Nutrimetabonomics” is today foreseen as a powerful approach for future nutritional programs tailored at health maintenance and disease prevention. Keywords: GC (Gas Chromatography); gut microbiota; MS (Mass Spectrometry); metabolomics; metabonomics; metabotypes; NMR (Nuclear