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Molecules 2005, 10, 1126-1134 molecules ISSN 1420-3049 New Multi-1,2,3-Selenadiazole Aromatic Derivatives Mousa Al-Smadi* and Samer Ratrout Department of Applied Chemical Sciences, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan * Author to whom correspondence should be addressed; e-mail: mariam10@.jo Received: 23 April 2005 / Published: 30 September 2005 Abstract: The aromatic polyketones 3a-d are versatile compounds for the synthesis of the multi-1,2,3-selenadiazole aromatic derivatives 1a-d. The preparation starts with the reaction between the multi-bromomethylene benzene derivatives 2a-d and 4-hydroxy- acetophenone to give compounds 3a-d which are transformed through the reaction with semicarbazide hydrochloride or ethyl hydrazine carboxylate into the corresponding semicarbazones derivatives 4a-d or hydrazones 5a-d. The reaction with selenium dioxide leads to regiospecific ring closure of semicarbazones or hydrazones to give the multi- 1,2,3-selenadiazole aromatic derivatives in high yield. Keywords: 1,2,3-Selenadiazoles; semicarbazones; aromatic derivatives Introduction Heterocyclic systems with multi-arm 1,2,3-thiadiazoles were recently prepared by Meier et. al [1- 2] and heterocyclic systems containing two 1,2,3-selenadiazole rings were also recently prepared by Reddy et. al [3-4], but multi-arm 1,2,3-selenadiazoles are still unknown. Therefore depending on the previous experience of the principal investigator in synthesizing multi-arm 1,2,3-thiadiazoles