原创力文档no effect of omeprazole on ph of exhaled breath condensate in cough associated with gastro-oesophageal reflux没有呼出气息的奥美拉唑对ph值的影响在咳嗽与gastro-oesophageal回流冷凝.pdfVIP
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no effect of omeprazole on ph of exhaled breath condensate in cough associated with gastro-oesophageal reflux没有呼出气息的奥美拉唑对ph值的影响在咳嗽与gastro-oesophageal回流冷凝
Cough BioMed Central
Research Open Access
No effect of omeprazole on pH of exhaled breath condensate in
cough associated with gastro-oesophageal reflux
Alfonso Torrego*, Stefan Cimbollek, Mark Hew and Kian Fan Chung
Address: Department of Thoracic Medicine, National Heart Lung Institute, Imperial College and Royal Brompton Hospital, London, UK
Email: Alfonso Torrego* - a.torrego@imperial.ac.uk; Stefan Cimbollek - scimbollek@; Mark Hew - m.hew@imperial.ac.uk;
Kian Fan Chung - f.chung@ic.ac.uk
* Corresponding author
Published: 19 October 2005 Received: 21 June 2005
Accepted: 19 October 2005
Cough 2005, 1:10 doi:10.1186/1745-9974-1-10
This article is available from: /content/1/1/10
© 2005 Torrego et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Endogenous airway acidification evaluated as pH in exhaled breath condensate
(EBC) has been described in patients with chronic cough. Proton pump inhibitors improve gastro-
oesophageal reflux (GOR)-associated cough.
Methods: We examined pH levels in EBC and capsaicin cough response in 13 patients with chronic
cough (mean age 41 years, SD 9) associated with GOR before and after omeprazole treatment (40
mg/day for 14 days) and its relationship with clinica
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