organocatalytic enantioselective henry reactions亨利organocatalytic拆分反应.pdfVIP

Symmetry 2011, 3, 220-245; doi:10.3390/sym3020220 OPEN ACCESS symmetry ISSN 2073-8994 /journal/symmetry Review Organocatalytic Enantioselective Henry Reactions Yolanda Alvarez-Casao 1, Eugenia Marques-Lopez 1 and Raquel P. Herrera 1,2,* 1 Laboratory of Asymmetric Synthesis, Department of Organic Chemistry, Institute of Synthetic Chemistry and Homogeneous Catalysis (ISQCH), University of Zaragoza-CSIC, E-50009 Zaragoza, Spain; E-Mails: yalvarezcasao@ (Y.A.-C.); mmaamarq@unizar.es (E.M.-L.) 2 ARAID, Aragon I+D Foundation, E-50004 Zaragoza, Spain * Author to whom correspondence should be addressed. E-Mail: raquelph@unizar.es; Tel.: +34 976762281; Fax: +34 976762075. Received: 29 March 2011; in revised form: 10 May 2011 / Accepted : 11 May 2011 / Published: 23 May 2011 Abstract: A large number of interesting organocatalytic enantioselective protocols have been explored and successfully applied in the last decade. Among them, the Henry (nitroaldol) reaction represents a powerful carbon-carbon bond-forming procedure for the preparation of valuable synthetic intermediates, such as enantioenriched nitro alcohols, which can be further transformed in a number of important nitrogen and oxygen-containing compounds. This area of research is still in expansion and a more complex version of this useful process has recently emerged, the domino Michael/Henry protocol, affording highly functionalized cycles with multiple stereogenic centers. Keywords: Henry; nitroaldol; organocatalysis; enantioselective; nitr