osteoarthritis associated with estrogen deficiency骨关节炎与雌激素缺乏有关.pdfVIP

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osteoarthritis associated with estrogen deficiency骨关节炎与雌激素缺乏有关.pdf

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osteoarthritis associated with estrogen deficiency骨关节炎与雌激素缺乏有关

Available online /content/11/5/241 Review Osteoarthritis associated with estrogen deficiency 1,2 3 1 1 Jorge A Roman-Blas , Santos Castañeda , Raquel Largo and Gabriel Herrero-Beaumont 1Bone and Joint Research Unit, Service of Rheumatology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid 28040, Spain 2Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia 19107, USA 3Department of Rheumatology, Hospital de la Princesa, Universidad Autónoma, Madrid 28005, Spain Corresponding author: Gabriel Herrero-Beaumont, gherrero@fjd.es Published: 21 September 2009 Arthritis Research Therapy 2009, 11:241 (doi:10.1186/ar2791) This article is online at /content/11/5/241 © 2009 BioMed Central Ltd Abstract estrogens [5]. In contrast to other tissues such as the Osteoarthritis (OA) affects all articular tissues and finally leads to endometrium, breast, brain and non-joint bone, it was joint failure. Although articular tissues have long been considered traditionally thought that joint tissues were non-responsive to unresponsive to estrogens or their deficiency, there is now estrogens and estrogen deficit. However, interest in estro- increasing evidence that estrogens influence the activity of joint gens was stimulated by the large proportion of postmeno- tissues through complex molecular pathways that act at multiple pausal women with OA and the complexit