osteoimmunology and osteoporosis近年来和骨质疏松症.pdfVIP

Geusens and Lems Arthritis Research Therapy 2011, 13:242 /content/13/5/242 R E V I E W Osteoimmunology and osteoporosis 1,2 3 Piet Geusens* and Willem F Lems Introduction Abstract h e concept of osteoimmunology emerged more than a The concept of osteoimmunology is based on decade ago and is based on rapidly growing insight into growing insight into the links between the immune the functional interdependence between the immune system and bone at the anatomical, vascular, system and bone at the anatomical, vascular, cellular, and cellular, and molecular levels. In both rheumatoid molecular levels [1]. In 1997, the receptor activator of the arthritis (RA) and ankylosing spondylitis (AS), bone nuclear factor-kappa-B ligand (RANKL)/RANK/osteo- is a target of inl ammation. Activated immune cells protegerin (OPG) pathway was identifi ed as a crucial at sites of inl ammation produce a wide spectrum molecular pathway of the coupling between osteoblasts of cytokines in favor of increased bone resorption and osteoclasts [2]. It appeared that not only osteoblasts in RA and AS, resulting in bone erosions, osteitis, but also activated T lymphocytes, which play a crucial and peri-inl ammatory and systemic bone loss. role in the pathogenesis of rheumatoid arthritis (RA), and Peri-inl ammatory bone formation is impaired in many other infl ammatory cells can produce RANKL, RA, resulting in