原创力文档overcoming multidrug resistance in human cancer cells by natural compounds克服人类肿瘤细胞多药耐药性的天然化合物.pdfVIP
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overcoming multidrug resistance in human cancer cells by natural compounds克服人类肿瘤细胞多药耐药性的天然化合物
Toxins 2010, 2, 1207-1224; doi:10.3390/toxins2061207
OPEN ACCESS
toxins
ISSN 2072-6651
/journal/toxins
Review
Overcoming Multidrug Resistance in Human Cancer Cells by
Natural Compounds
Tomohiro Nabekura
Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences,
Higashi-jima, Akiha -ku, Niigata 956-8603, Japan; E-Mail: nabe@nupals.ac.jp; Tel.: +81-250-25-5000;
Fax: +81-250-25-5021
Received: 30 April 2010; in revised form: 26 May 2010 / Accepted: 27 May 2010 /
Published: 28 May 2010
Abstract: Multidrug resistance is a phenomenon whereby tumors become resistant to
structurally unrelated anticancer drugs. P-glycoprotein belongs to the large ATP-binding
cassette (ABC) transporter superfamily of membrane transport proteins. P-glycoprotein
mediates resistance to various classes of anticancer drugs including vinblastine,
daunorubicin, and paclitaxel, by actively extruding the drugs from the cells. The quest for
inhibitors of anticancer drug efflux transporters has uncovered natural compounds,
including (-)-epigallocatechin gallate, curcumin, capsaicin, and guggulsterone, as
promising candidates. In this review, studies on the effects of natural compounds on
P-glycoprotein and anticancer drug efflux transporters are summarized.
Keywords: P-glycoprotein; ABC transporter; anticancer drug; multidrug resistance;
phytochemical; cancer ch
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