ovariectomized rats as a model of postmenopausal osteoarthritis validation and application切除卵巢的老鼠绝经后骨关节炎模型的验证和应用.pdfVIP

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ovariectomized rats as a model of postmenopausal osteoarthritis validation and application切除卵巢的老鼠绝经后骨关节炎模型的验证和应用.pdf

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ovariectomized rats as a model of postmenopausal osteoarthritis validation and application切除卵巢的老鼠绝经后骨关节炎模型的验证和应用

Available online /content/6/2/R169 Research article Open Access Ovariectomized rats as a model of postmenopausal osteoarthritis: validation and application 1 2 1 1 Pernille Høegh-Andersen , László B Tankó , Thomas L Andersen , Carina V Lundberg , John A Mo1 1 1 1 , Anne-Marie Heegaard , Jean-Marie Delaissé and Stephan Christgau 1Nordic Bioscience A/S, Herlev Hovedgade 207, 2730 Herlev, Denmark 2Center for Clinical and Basic Research, Ballerup Byvej 222, 2750 Ballerup, Denmark Corresponding author: Pernille Høegh-Andersen (e-mail: pha@NordicB) Received: 17 Oct 2003 Revisions requested: 31 Oct 2003 Revisions received: 14 Jan 2004 Accepted: 21 Jan 2004 Published: 19 Feb 2004 Arthritis Res Ther 2004, 6:R169-R180 (DOI 10.1186/ar1152) © 2004 Høegh-Andersen et al., licensee BioMed Central Ltd (Print ISSN 1478-6354; Online ISSN 1478-6362). This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the articles original URL. Abstract We aimed to assess the effect of ovariectomy on cartilage (P = 0.008). Ovariectomy also significant increased CTX-I turnover and degradation, to evaluate whether ovariectomized and CTX-II. Both the absolute levels of CTX-II and the relative (OVX) rats could form an experimental model of changes from baseline seen at week 4 correlated strong