oxazolone-induced delayed type hypersensitivity reaction in the adult yucatan pigs. a useful model for drug development and validationoxazolone-induced延迟型过敏反应在成年人的尤卡坦半岛的猪。.pdfVIP

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oxazolone-induced delayed type hypersensitivity reaction in the adult yucatan pigs. a useful model for drug development and validationoxazolone-induced延迟型过敏反应在成年人的尤卡坦半岛的猪。.pdf

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oxazolone-induced delayed type hypersensitivity reaction in the adult yucatan pigs. a useful model for drug development and validationoxazolone-induced延迟型过敏反应在成年人的尤卡坦半岛的猪。

Toxins 2009, 1, 25-36; doi:10.3390/toxins1010025 OPEN ACCESS toxins ISSN 2072-6651 /journal/toxins Article Oxazolone-Induced Delayed Type Hypersensitivity Reaction in the Adult Yucatan Pigs. A Useful Model for Drug Development and Validation Samer Nuhaily 1, Bassam B. Damaj 2,* and Azzam A. Maghazachi 3,* 1 Division of Rheumatology and Immunology, University of Virginia, USA 2 Bio-Quant, Inc., San Diego, CA, USA 3 Department of Physiology, Faculty of Medicine, University of Oslo, Norway * Authors to whom correspondence should be addressed; E-Mails: bdamaj@ (B.B.D.); azzam.maghazachi@medisin.uio.no (A.A.M.). Received: 29 July 2009; in revised form: 19 August 2009 / Accepted: 21 August 2009 / Published: 21 August 2009 Abstract: The purpose of this study was to establish a model of delayed type hypersensitivity (DTH) reaction in the ear skin of large animals such as adult Yucatan pigs, which may aid in evaluating the efficacy of therapeutic modalities of newly developed anti-inflammatory drugs. The pigs were sensitized with oxazolone, re-challenged with the same irritant six days later, and dosed with either vehicle or with cyclosporine A (CsA) before and after challenge. CsA reduced the redness, inhibited the accumulation of ear fluid and inflammatory cells, as well as the release of the inflammatory mediators. Further, CsA inhibited the proliferation of T cells collected from the spleens or PBMCs of CsA-treated pigs when the