oxime esters of 2,6-diazaanthracene-9,10-dione and 4,5-diazafluoren-9-one as photo-induced dna-cleaving agents肟酯类2、6-diazaanthracene-9 10-dione和4,5-diazafluoren-9-one photo-induced dna-cleaving代理.pdfVIP

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oxime esters of 2,6-diazaanthracene-9,10-dione and 4,5-diazafluoren-9-one as photo-induced dna-cleaving agents肟酯类2、6-diazaanthracene-9 10-dione和4,5-diazafluoren-9-one photo-induced dna-cleaving代理.pdf

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oxime esters of 2,6-diazaanthracene-9,10-dione and 4,5-diazafluoren-9-one as photo-induced dna-cleaving agents肟酯类2、6-diazaanthracene-9 10-dione和4,5-diazafluoren-9-one photo-induced dna-cleaving代理

Molecules 2012, 17, 3370-3382; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Oxime Esters of 2,6-Diazaanthracene-9,10-dione and 4,5-Diazafluoren-9-one as Photo-induced DNA-Cleaving Agents Shang-Shing P. Chou 1,*, Jui-Chi Juan 1, Shwu-Chen Tsay 2, Kuei Pin Huang 2 and Jih Ru Hwu 2,3,* 1 Department of Chemistry, Fu Jen Catholic University, New Taipei 24205, Taiwan; E-Mail: .tw 2 Department of Chemistry, National Central University, Jhongli 32001, Taiwan; E-Mails: tsay.susan@ (S-C.T.); koala790901@ (K.P.H.) 3 Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan * Authors to whom correspondence should be addressed; E-Mails: chem1004@.tw (S.-S.P.C.); jrhwu@.tw (J.R.H.); Tel.: +886-2-2905-2474 (S.-S.P.C.); Fax: +886-2-2902-3209 (S.-S.P.C.); Tel.: +886-3-425-4287(J.R.H.); Fax: +886-3-280-4316 (J.R.H.). Received: 29 January 2012; in revised form: 10 March 2012 / Accepted: 12 March 2012 / Published: 15 March 2012 Abstract: Two series of oxime esters containing the 2,6-diazaanthracene-9,10-dione bis-(O-benzoyloxime) and 4,5-diazafluoren-9-one O-9-benzoyloxime moieties have been synthesized and tested as photo-induced DNA cleaving agents. All these compounds were found to cleave DNA upon irradiation with 312 nm UV light. The structure-activity relationship of these molecules for DNA cleavage was established. A plausible reaction mechanism is also proposed. Keywords: photo-induced