p5l mutation in ank results in an increase in extracellular inorganic pyrophosphate during proliferation and nonmineralizing hypertrophy in stably transduced atdc5 cells⊙用途制造p5l突变导致增加细胞外焦磷酸无机在扩散和稳定转导atdc5 nonmineralizing肥大细胞.pdfVIP

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p5l mutation in ank results in an increase in extracellular inorganic pyrophosphate during proliferation and nonmineralizing hypertrophy in stably transduced atdc5 cells⊙用途制造p5l突变导致增加细胞外焦磷酸无机在扩散和稳定转导atdc5 nonmineralizing肥大细胞.pdf

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p5l mutation in ank results in an increase in extracellular inorganic pyrophosphate during proliferation and nonmineralizing hypertrophy in stably transduced atdc5 cells⊙用途制造p5l突变导致增加细胞外焦磷酸无机在扩散和稳定转导atdc5 nonmineralizing肥大细胞

Available online /content/8/6/R164 Vol 8 No 6 Open Access Research article P5L mutation in Ank results in an increase in extracellular inorganic pyrophosphate during proliferation and nonmineralizing hypertrophy in stably transduced ATDC5 cells 1 1 2 1 1 1 Raihana Zaka , David Stokes , Arnold S Dion , Anna Kusnierz , Fei Han and Charlene J Williams 1Division of Rheumatology, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA 2College of Graduate Studies, Thomas Jefferson University, Philadelphia, PA 19107, USA Corresponding author: Charlene J Williams, charlene.williams@ Received: 10 Aug 2006 Revisions requested: 30 Aug 2006 Revisions received: 5 Oct 2006 Accepted: 26 Oct 2006 Published: 26 Oct 2006 Arthritis Research Therapy 2006, 8:R164 (doi:10.1186/ar2072) This article is online at: /content/8/6/R164 © 2006 Zaka et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Ank is a multipass transmembrane protein that regulates the transduced cells. The cell line expressing the proline to leucine cellular transport of inorganic pyrophosphate. In the progressive mutation at position 5 (P5L) consistently displayed higher levels ankylosis (ank) mouse, a premature termination mutation at of extracellular inorganic pyrophosphate and higher