p53 tumor suppressor gene mutations in fibroblast-like synoviocytes from erosion synovium and non-erosion synovium in rheumatoid arthritisp53肿瘤抑制基因的突变呈synoviocytes侵蚀滑膜和non-erosion风湿性关节炎滑膜.pdfVIP

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p53 tumor suppressor gene mutations in fibroblast-like synoviocytes from erosion synovium and non-erosion synovium in rheumatoid arthritisp53肿瘤抑制基因的突变呈synoviocytes侵蚀滑膜和non-erosion风湿性关节炎滑膜.pdf

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p53 tumor suppressor gene mutations in fibroblast-like synoviocytes from erosion synovium and non-erosion synovium in rheumatoid arthritisp53肿瘤抑制基因的突变呈synoviocytes侵蚀滑膜和non-erosion风湿性关节炎滑膜

Available online /content/7/1/R12 Vol 7 No 1 Open Access Research article p53 tumor suppressor gene mutations in fibroblast-like synoviocytes from erosion synovium and non-erosion synovium in rheumatoid arthritis 1,2 2 3 4 4 Yuji Yamanishi , David L Boyle , Douglas R Green , Edward C Keystone , Alison Connor , Susan Zollman4 and Gary S Firestein2 1Department of Rheumatology, Hiroshima City Hospital, Hiroshima, Japan 2Division of Rheumatology, Allergy, and Immunology, School of Medicine, University of California at San Diego, La Jolla, California, USA 3La Jolla Institute of Allergy and Immunology, La Jolla, California, USA 4Department of Medicine, University of Toronto, Canada Corresponding author: Gary S Firestein, gfirestein@ Received: 9 May 2004 Revisions requested: 8 Jun 2004 Revisions received: 9 Aug 2004 Accepted: 8 Sep 2004 Published: 29 Oct 2004 Arthritis Res Ther 2005, 7:R12-R18 (DOI 10.1186/ar1448) /content/7/1/R12 © 2004 Yamanishi et al., licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/ 2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is cited. Abstract Abnormalities in the p53 tumor suppressor gene have been to the frequency or type of p53 mutation. The majority of the detected in rheumatoid arthritis (RA) and could contribute to the mutations were missense transi