pain persists in das28 rheumatoid arthritis remission but not in acreular remission a longitudinal observational study疼痛坚持das28风湿性关节炎缓解而不是acreular缓解纵向观察研究.pdfVIP

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pain persists in das28 rheumatoid arthritis remission but not in acreular remission a longitudinal observational study疼痛坚持das28风湿性关节炎缓解而不是acreular缓解纵向观察研究.pdf

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pain persists in das28 rheumatoid arthritis remission but not in acreular remission a longitudinal observational study疼痛坚持das28风湿性关节炎缓解而不是acreular缓解纵向观察研究

Lee et al. Arthritis Research Therapy 2011, 13:R83 /content/13/3/R83 RESEARCH ARTICLE Open Access Pain persists in DAS28 rheumatoid arthritis remission but not in ACR/EULAR remission: a longitudinal observational study * Yvonne C Lee , Jing Cui, Bing Lu, Michelle L Frits, Christine K Iannaccone, Nancy A Shadick, Michael E Weinblatt and Daniel H Solomon Abstract Introduction: Disease remission has become a feasible goal for most rheumatoid arthritis (RA) patients; however, patient-reported symptoms, such as pain, may persist despite remission. We assessed the prevalence of pain in RA patients in remission according to the Disease Activity Score (DAS28-CRP4) and the American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) remission criteria. Methods: Data were analyzed from RA patients in the Brigham Rheumatoid Arthritis Sequential Study with data at baseline and 1 year. DAS28 remission was defined as DAS28-CRP4 2.6. The ACR/EULAR remission criteria included (a) one or more swollen joints, (b) one or more tender joints, (c) C-reactive protein ≤1 mg/dl, and (d) patient global assessment score ≤1. Pain severity was measured by using the pain score from the Multi-Dimensional Health Assessment Questionnaire (MDHAQ). The associations between baseline clinical predictors and MDHAQ pain at baseline and 1 year were assessed by using multivariable linear regression. Results: Among the 865 patients with data at baseline and 1 year, 157 (18.2%) met DAS28-CRP4 remission criteria at both time points. Thirty-seven (4.3%) met the ACR/EULAR remission criteria at baseline and 1 year. The prevalence of clinically significant pain (MDHAQ pain ≥4) at baseline ranged from 11.9% among patients meeting DAS28-CRP4 remission criteria to none among patients meeting ACR/EULAR remission criteria. Pati