pentamethylquercetin improves adiponectin expression in differentiated 3t3-l1 cells via a mechanism that implicates pparγ together with tnf-α and il-6pentamethylquercetin改善脂联素表达分化3 t3-l1细胞通过一种机制,这其中牵扯到一起pparγtnf-α和il - 6.pdfVIP

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pentamethylquercetin improves adiponectin expression in differentiated 3t3-l1 cells via a mechanism that implicates pparγ together with tnf-α and il-6pentamethylquercetin改善脂联素表达分化3 t3-l1细胞通过一种机制,这其中牵扯到一起pparγtnf-α和il - 6.pdf

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pentamethylquercetin improves adiponectin expression in differentiated 3t3-l1 cells via a mechanism that implicates pparγ together with tnf-α and il-6pentamethylquercetin改善脂联素表达分化3 t3-l1细胞通过一种机制,这其中牵扯到一起pparγtnf-α和il - 6

Molecules 2011, 16, 5754-5768; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Pentamethylquercetin Improves Adiponectin Expression in Differentiated 3T3-L1 Cells via a Mechanism that Implicates PPARγ together with TNF-α and IL-6 Lei Chen, Ting He, Yi Han, Ji-Zhong Sheng, Si Jin and Man-Wen Jin * Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; E-Mail: clean829940@ (L.C.) * Author to whom correspondence should be addressed; E-Mail: tjmwjin@163.com; Tel.: +86-027 Fax: +86-027 Received: 18 April 2011; in revised form: 23 June 2011 / Accepted: 1 July 2011 / Published: 6 July 2011 Abstract: Adiponectin is an adipocyte-derived hormone that plays a pivotal role in the regulation of lipid and glucose metabolism. Up-regulation of adiponectin expression and production has been shown to benefit for metabolic disorders, including type 2 diabetes, hyperlipidemia, etc. The present study investigated whether the novel polymethoxylated flavonoid pentamethylquercetin (PMQ), a member of polymethoxylated flavonoids family which is present in seabuckthorn (Hippophae L.) would affect adiponectin production in differentiated 3T3-L1 adipocytes. It was found that PMQ increased the adiponectin mRNA and protein expressions in adipocytes in time- and concentration-dependent manners. The PPARγ pathway plays a important roles in this effect of PMQ because blockade of PPARγ by GW9662 elimin