原创力文档perivascular mesenchymal stem cells in the adult human brain a future target for neuroregeneration血管周的间充质干细胞在成人大脑本次的未来目标.pdf
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perivascular mesenchymal stem cells in the adult human brain a future target for neuroregeneration血管周的间充质干细胞在成人大脑本次的未来目标
Özen et al. Clinical and Translational Medicine 2012, 1:30
/content/1/1/30
REVIEW Open Access
Perivascular mesenchymal stem cells in the
adult human brain: a future target for
neuroregeneration?
1 1 1,2*
Ilknur Özen , Jordi Boix and Gesine Paul
Abstract
Perivascular adult stem cells have been isolated from several tissues, including the adult human brain. They have
unique signatures resembling both pericytes and mesenchymal stem cells. Understanding the nature of these cells
in their specific vascular niches is important to determine their clinical potential as a new adult stem cell source.
Indeed, they have promising features in vitro in terms of multipotency, immunomodulation and secretion of growth
factors and cytokines. However, their in vivo function is less known as yet. Recent emerging data show a crucial role
of perivascular mesenchymal stem cells in tissue homeostasis and repair. Furthermore, these cells may play an
important role in adult stem cell niche regulation and in neurodegeneration. Here we review the recent literature
on perivascular mesenchymal stem cells, discuss their different in vitro functions and highlight especially the
specific properties of brain-derived perivascular mesenchymal stem cells. We summarize current evidence that
suggests an important in vivo function of these cells in terms of their regenerative potential that may indicate a
new target cell for endogenous tissue regeneration and repair.
Keywords: Pericytes, Mesenchymal stem cells, Perivascular niche, Neuroregeneration
Review In contrast to embryonic stem cells, the differentiation
Adult stem cells potential of ASCs is regarde
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