peripapillary choroidal neovascularization in pars planitis在幼虫视神经盘旁脉络膜的新血管形成.pdf

Mehta et al. Journal of Opthalmic Inflammation and Infection 2013, 3:13 /content/3/1/13 BRIEF REPORT Open Access Peripapillary choroidal neovascularization in pars planitis 1,2 2 3 2,4,5* Sonia Mehta , Luxme Hariharan , Allen C Ho and John H Kempen Abstract Background: Choroidal neovascularization (CNV) is a rare complication of intermediate uveitis. Risk factors are not well-characterized. Here, we describe a case of peripapillary CNV in a patient with intermediate uveitis and explore the pathophysiology and treatment of this condition. This study is a case report and review of the literature. Results: A 15-year-old boy with intermediate uveitis - suppressed for the preceding year on immunosuppressive therapy and low-dose corticosteroids - and chronic disc swelling presented with unilateral metamorphopsia, peripapillary subretinal hemorrhage, and subretinal fluid. Fluorescein angiogram confirmed the presence of an active choroidal neovascular membrane. Treatment with intravitreal bevacizumab 1.25 mg every 4 weeks for 4 months resulted in resolution of subretinal fluid, subretinal hemorrhage, and regression of the CNV. The patients intermediate uveitis remained inactive throughout this time. Conclusion: Review of the existing literature and pathophysiologic consideration suggests that chronic disc edema may be a risk factor for this condition. Peripapillary CNV in the context of intermediate uveitis appears to respond well to VEGF-inhibitor therapy. Keywords: Choroidal neovascularization, CNV, Intermediate uveitis, Pars planitis, Peripapillary Findings the approval of the governing Institutional Review Board Background