parenteral nutrition additive shortages the short-term, long-term and potential epigenetic implications in premature and hospitalized infants肠外营养添加剂短缺的短期、长期、潜在的表观遗传影响早产儿和婴儿住院.pdf

Nutrients 2012, 4, 1977-1988; doi:10.3390/nu4121977 OPEN ACCESS nutrients ISSN 2072-6643 /journal/nutrients Review Parenteral Nutrition Additive Shortages: The Short-Term, Long-Term and Potential Epigenetic Implications in Premature and Hospitalized Infants Corrine Hanson 1,*, Melissa Thoene 2, Julie Wagner 3, Dean Collier 4, Kassandra Lecci 2 and 5 Ann Anderson-Berry 1 School of Allied Health Professionals, University of Nebraska Medical Center, Omaha, NE 984045, USA 2 Pharmacy and Nutrition Care Services, Nebraska Medical Center, Omaha, NE 984045, USA; E-Mails: mthoene@ (M.T.); klecci@ (K.L.) 3 Alegent Health Bergan Mercy Medical Center, 7500 Mercy Road, Omaha, NE 68124, USA; E-Mail: Julie.wagner@ 4 College of Pharmacy, University of Nebraska Medical Center, Omaha, NE 986045, USA; E-Mail: dcollier@ 5 College of Pediatrics, University of Nebraska Medical Center, Omaha, NE 981205, USA; E-Mail: alanders@ * Author to whom correspondence should be addressed; E-Mail: ckhanson@; Tel.: +1-402-559-3658; Fax: +1-402-559-7565. Received: 12 October 2012; in revised form: 29 November 2012 / Accepted: 30 November 2012 / Published: 7 December 2012 Abstract: Nutrition support practitioners are currently dealing with shortages of parenteral nutrition micronutrients, including multivitamins (MVI), selenium and zinc. A recent survey from the American Society of Enteral and Parenteral Nutrition (ASPEN) indicates that this shortage is having a profound effect on clinical practice. A majority of respondent